This is the second paper in a series presenting the results from a 500 h−1Mpc large constrained simulation of the local Universe (SLOW). The initial conditions for this cosmological hydro-dynamical simulation are based on peculiar velocities derived from the CosmicFlows-2 catalog. The simulation follows cooling, star formation, and the evolution of super-massive black holes. This allows one to directly predict observable properties of the intracluster medium (ICM) within galaxy clusters, including X-ray luminosity, temperatures, and the Compton-y signal.